Thymosin Alpha 1 research: overview and resources
What Thymosin Alpha 1 research material is, how it is characterized, and where to find every specification, method, lot record and reference Thymosin Alpha Labs publishes about it.
What is Thymosin Alpha 1?
Thymosin Alpha 1 (thymosin α1) is a 28-residue peptide, acetylated at its N-terminus, that was first isolated from thymosin fraction 5, an extract of calf thymus. It is cut from the precursor protein prothymosin α. The sequence is strongly acidic, with seven glutamates and three aspartates against four lysines, so the molecule carries a large net negative charge at neutral pH, and it has no aromatic residues and no cysteine. Thymosin α1 is studied in immunology research for its effects on T-cell maturation in laboratory models.
Thymosin Alpha Labs supplies it as a lyophilized powder in 5 mg vials through Klow.bio. Each lot is tested by an independent laboratory for HPLC-UV purity, LC-MS identity and net content, and its certificate is published here.
What is Thymosin Alpha 1 research material?
Thymosin Alpha 1 research material is Thymosin Alpha 1 supplied for laboratory research (C129H215N33O55, 3108.32 g/mol) in white lyophilized powder form, sold by lot. Each lot's identity, purity and net content are documented by an independent laboratory in a published certificate of analysis.
How is Thymosin Alpha 1 characterized?
Three questions are answered for every lot, each by a different method:
- Is it the right compound? LC-MS separates the sample and measures the mass of the main component, confirming it has the molecular weight expected for the compound.
- How much of the sample is that compound? HPLC-UV reports the main peak's share of detected peak area. Current lots: .
- How much peptide is in the vial? Net content is measured directly.
Endotoxin (LAL) and microbial DNA (PCR) results are added where those tests are run.
What has not been established
A certificate of analysis describes the specific sample tested on its test date. It does not establish stability afterward, sequence order beyond what mass confirmation shows, results for other lots, or suitability for any particular purpose.
Thymosin Alpha 1 at a glance
- Product
- Thymosin Alpha 1
- Type
- Synthetic 28-residue acetylated peptide, 28 residues
- Also known as
- Thymosin α1, Tα1
- CAS number
- 62304-98-7
- Molecular formula
- C129H215N33O55
- Molecular weight
- 3108.32 g/mol (average)
- Form
- White lyophilized powder
- Vial sizes
- 5 mg
- Purity, current lots
- Certificate in progress
- Purity specification
- ≥95%
- Identity
- Confirmed by LC-MS on every lot
- Testing laboratory
- Freedom Diagnostics (independent)
- Operated by
- Klow Labs LLC, Chicago, IL
- Where to order
- klow.bio
Thymosin Alpha 1 research resources
Every Thymosin Alpha 1 resource on thymosinalpha.bio, organized from chemistry to documentation.
Thymosin Alpha 1 specifications
Formula, molecular weight, sequence, modifications and release specification.
QualityQuality and supply chain
Sourcing, specifications, batch documentation and release.
TestingAnalytical testing
How every lot is tested, reviewed and released.
TestingHPLC analysis of Thymosin Alpha 1
Retention time, peaks, area normalization and results by lot.
DocumentationCertificates of analysis
Every lot's full results, plus the complete testing records.
DocumentationHow to read a Thymosin Alpha 1 COA
What each section means and what a COA does and doesn't establish.
DocumentationVerify a lot
Look up any Thymosin Alpha 1 lot by the number on the vial.
AnalysisPurity, content and net content
Three different numbers, kept apart.
HandlingStorage and stability
Degradation pathways and lyophilized peptide handling.
ReferenceGlossary
Definitions for every term on a Thymosin Alpha 1 certificate.
Research materialThymosin Alpha 1 research material
Sizes, current lots and availability. Purchasing is handled through Klow.bio.
Research references
Published sources
- PubChem: Thymalfasin (thymosin alpha 1). National Library of Medicine, NIH. pubchem.ncbi.nlm.nih.gov/compound/16130571
- NCBI Gene: PTMA (prothymosin alpha). National Center for Biotechnology Information, NIH. www.ncbi.nlm.nih.gov/gene/5757
- Wilm M. Principles of electrospray ionization. Mol Cell Proteomics. 2011. PMC3134074. pmc.ncbi.nlm.nih.gov/articles/PMC3134074
- U.S. FDA. Q2(R2) Validation of Analytical Procedures. 2024. fda.gov
- U.S. FDA. Pyrogen and Endotoxins Testing: Questions and Answers. Revised 2026. fda.gov
Thymosin Alpha Labs analytical documentation
- Thymosin Alpha 1 testing records (all tests, all lots; CSV available)
Editorial scope
Thymosin Alpha Labs research content covers molecular characteristics, peptide structure, analytical chemistry, purity and identity testing, certificates of analysis, lot documentation and laboratory storage and handling.
It does not cover dosing, administration instructions, protocols, personal use or medical advice.
Latest updates
Buy Thymosin Alpha 1
5 mg vials. The current batch's certificate is in progress. Current purchasing is available through Klow.bio.